According to epidemiological surveys, among people under age of 50, 9%-42% of people suffer from mild hyperhomocysteinaemia. These people are likely to suffer from thromboembolism, myocardial ischemia, and peripheral arteries, cardiovascular and cerebrovascular diseases such as occlusion or cerebral artery occlusion. Among the affected population, the prevalence rate is very high especially among women.

Hyperhomocystinemia is caused by the lack of nutrients that provide methyl groups in the food (mainly betaine, the physiological function is to prevent the extravasation of water in the cells and keep the volume and function of the cells normal. The body provides sufficient methyl), the circulation of methionine in the body is blocked, and homocysteine ​​cannot be converted into methionine which is caused by accumulation in the blood. Increasing the intake of foods rich in betaine will alleviate many diseases caused by hyperhomocysteinemia and reduce the risk of cardiovascular disease

Experts point out that choline in the human body can be converted into betaine, but choline is the main raw material for the synthesis of acetylcholine and phospholipids, and is an essential component for maintaining normal brain nutrition. Usually only a small amount of choline is converted back into betaine. Therefore, the human body's demand for betaine mainly depends on diet, and the safe dosage of betaine is 9-15 grams per day.