Interaction of betaine with methionine, choline and lysine
01 Betaine function
Relieve heat stress, synergize with anticoccidial drugs, regulate intestinal osmotic pressure; improve slaughter rate and lean meat rate, improve carcass quality, no residue and no toxicity; piglet attractant, prevent piglet diarrhea; is a variety of aquatic animals Excellent food attractant, prevent fatty liver, relieve seawater conversion, improve the survival rate of fry; compared with choline chloride, it will not destroy the activity of vitamins. Betaine can replace part of methionine and choline in feed formulations, reducing feed costs without reducing poultry performance.
02 The role of methionine
Methionine is an essential sulfur-containing amino acid and is closely related to the metabolism of various sulfur-containing compounds in living organisms. When methionine is deficient, it can cause loss of appetite, slowed growth or no weight gain, enlarged kidneys, and iron accumulation in the liver, which can eventually lead to liver necrosis or fibrosis.
Methionine can also use its methyl group to methylate toxic substances or drugs to detoxify. Therefore, methionine can be used to prevent and treat chronic or acute hepatitis, liver cirrhosis and other liver diseases, and can also be used to alleviate the toxic reactions of harmful substances such as arsenic, chloroform, carbon tetrachloride, benzene, pyridine and quinoline.
03 The role of lysine
Lysine is a basic essential amino acid. Because the content of lysine in cereal food is very low, and it is easily damaged and lacking during processing, it is called the first limiting amino acid.
Lysine can regulate the body's metabolic balance. Lysine provides the structural component for the synthesis of carnitine, which promotes fatty acid synthesis in cells. Adding a small amount of lysine to food can stimulate the secretion of pepsin and gastric acid, improve the secretion of gastric juice, increase appetite, and promote the growth and development of young children. Lysine also improves calcium absorption and its accumulation in the body, accelerating bone growth. Such as lack of lysine, it will cause insufficient secretion of gastric juice and anorexia, nutritional anemia, resulting in central nervous system obstruction, dysplasia.
Lysine can also be used as an auxiliary drug for diuretics in medicine to treat lead poisoning caused by the reduction of chloride in the blood. It can also be used with acidic drugs (such as salicylic acid, etc.) to form salts to reduce adverse reactions. Combined use with methionine It can inhibit severe hypertension.
04 Trimethylglycine
Betaine replacement nutrition mechanism Animal production Betaine (Betaine), also known as trimethylglycine, chemical name is trimethylaminoglycolide, molecular formula is C5H11O2N, is a quaternary amine alkaloid. It has three active methyl groups, which are indispensable substances in animals, and has 2 methyl groups more than methionine. It is a high-efficiency methyl donor.
Physicochemical properties of betaine Betaine is a white prismatic or leaf-like crystal with a melting point of 293°C and a sweet taste. The hydrated form of betaine is soluble in water, soluble in methanol and ethanol, and slightly soluble in ether. It has strong moisturizing properties, and is easily hygroscopic and deliquescent at room temperature. Betaine is very stable, resistant to high temperature of 200 ℃, and has strong antioxidant properties. The toxicity test proved that betaine is drug-free.
05 The role of betaine
Betaine can ensure the methyl requirements for participating in various biochemical reactions in animals to ensure the normal synthesis and metabolism of nucleic acids and proteins. It can promote fat metabolism, improve lean meat rate, prevent fatty liver, and enhance immune function. It can regulate cell osmotic pressure, reduce stress response, and ensure the normal growth of animals. It can stimulate the sense of smell and taste of animals, and is a good food attractant, especially for aquatic animals, it has the functions of increasing food intake and survival rate, reducing bait coefficient, and promoting growth. Betaine is compatible with vitamins in premixed feed, and can maintain higher stability of vitamins than choline.
06 Recommended ways to save choline
98% betaine hydrochloride : 50% choline chloride =1:3.12
Choline in poultry raw materials is generally used for metabolic functions of the body, such as phospholipid synthesis and fat metabolism. Under this condition, the choline chloride added exogenously can be completely replaced according to the equivalent of the above formula.
This recommended method of use does not apply to pigs. Because choline mainly has the functions of regulating fat metabolism and improving amino acid utilization in pigs, when the choline in the raw material cannot meet the metabolic needs or the utilization rate of the raw material choline is low, choline can be considered in the piglet diet. In general, the raw material of choline for growing and finishing pigs basically meets the needs.
However, the addition of betaine to the piglet diet has the effect of attracting food and preventing diarrhea. Adding betaine to growing-finishing pig diets can improve carcass quality.
07 Recommended usage for saving methionine
Betaine cannot completely replace methionine because betaine cannot replace methionine for protein synthesis. As far as the current poultry nutrition requirements are concerned, betaine can generally replace 15-25% of synthetic methionine without affecting production performance.
When the methionine requirement in the compound feed is designed to be very low, and the poultry feed intake is less in summer, it is easy to cause a significant lack of methionine, resulting in feather pecking, slow growth, and low feed efficiency. At this time, the addition of betaine in the diet plays a role in supplying methyl groups for methionine and increases the insurance factor.
Betaine can not only provide methyl, but also has the effect of regulating osmotic pressure when the amount added to the feed is at least 700g/T. In the case of severe osmotic shock, the recommended dosage of betaine is 1-1.5kg/T.
Betaine hydrochloride (98%) L-methionine (98%) = 1:1.03 (for reference only!)