Betaine has been shown to be beneficial for a variety of human diseases, including obesity, diabetes, cancer and Alzheimer's disease.

The study found that the higher the betaine intake, the better the body composition, when analyzed in a large general population. Similarly, other studies have shown a negative association between plasma betaine concentration and nonalcoholic fatty liver disease in humans, but the results of betaine supplementation are debatable. Therefore, more research is needed to focus on this area in order to obtain reliable results.

Multiple animal studies have shown that betaine is closely related to diabetes mellitus. Diabetes leads to elevated blood sugar due to impaired glucose metabolism. Plasma betaine concentration is a poor predictor for the diagnosis of diabetes in humans and may be associated with diabetic complications such as microangiopathopathy. Studies have shown that abnormal urinary betaine excretion is closely associated with diabetes, but of less diagnostic value than other substances such as choline and dimethylglycine.

Many studies have found that betaine intake has a positive effect on the prevention of cancers such as breast, lung, liver, colorectal and nasopharyngeal cancers. In these studies, higher betaine intake was associated with a lower risk of cancer. In addition, studies have shown that consumption of choline and betaine (100mg/ day) can reduce the incidence of cancer by 11%.Betaine intervention restores hyperhomocysteine-induced Alzheimer's disease and reduces the inflammatory response in alzheimer's patients. This discovery further expands the range of applications of betaine in human disease.