At present, drug treatment is still the main means of coccidiosis prevention and control, but with the widespread emergence of coccidiosis resistance, the effect of many anti-coccidiosis drugs is getting worse and worse, and Coccidia are becoming more and more resistant. Polyether antibiotics such as halomycin and Maduramycin are the main anti-coccidiosis drugs used in chicken farms at present, and have been widely added and used in feed. But the existing drugs in the destruction of cell membrane permeability to achieve the purpose of killing coccidioides at the same time, will also act on the tissue cells of the body, so that the ion disorder in chickens, chicken intestinal cells have a negative impact on the absorption function of intestinal epithelial cells, easy to cause the absorption function of chicken intestinal epithelial cells decline.

Betaine is an alkaloid with antioxidant properties. Some of reported that the combination of antioxidants and polyether antibiotics can reduce the toxicity of polyether antibiotics, especially when polyether antibiotics are combined with other antibiotics, it can help to reduce or eliminate the adverse reactions. Betaine is order to osmotic pressure to the effective buffer material, when the osmotic pressure change, betaine can be absorbed by the cells, improve membrane Na/K pump function, by supplementing potassium ion, and reduce the loss of osmotic pressure when the abnormal water and salts of invasion, maintain normal osmotic pressure balance, involved in maintaining the integrity of the tissue cells and function, reduce intestinal stress, It can improve the electrolyte balance of the body.

Betaine can improve the tolerance of chicken intestinal cells to changes in osmotic pressure caused by the anti-coccidiosis drugs, and produce synergistic effect through the degradation of drugs, reduce the tissue damage caused by coccidiosis, reduce or prevent diarrhea, improve the absorption function of intestinal cells, and better control the occurrence of subclinical coccidiosis. Betaine could significantly reduce the invasitivity of coccidiasis and inhibit the reproduction of schizozoites of Giant Eimeria. Ding Xicheng study found that such as electrolyte balance disorder is one of the leading causes of death chicken coccidiosis infection, Betaine has obvious anti-coccidiosis effect, through supplementing potassium ease chicks electrolyte disorder caused by infection with Eimeria, and it inhibited the effect of the Giant Eimeria fission reproduction, so achieve the purpose of curing, Maduramycin, on the other hand, had little effect on electrolyte imbalance when controlling coccidial infection.